Product Description
Imaford-400 belongs to a class of drugs known as tyrosine kinase inhibitors (TKIs). Unlike conventional chemotherapy, which attacks all rapidly dividing cells, this medication targets specific faulty proteins (such as the BCR-ABL fusion protein and c-KIT) that function as unregulated biological switches. By turning off these switches, it stops cancer cells from proliferating and causes them to safely die off.
Clinical Indications
This medication is primarily prescribed under strict oncological supervision for:
- Chronic Myeloid Leukemia (CML): A type of blood cancer marked by a specific chromosomal abnormality (the Philadelphia chromosome).
- Acute Lymphocytic Leukemia (Ph+ ALL): An aggressive form of blood cancer.
- Gastrointestinal Stromal Tumors (GIST): Rare tumors originating in the walls of the digestive tract.
- Other Rare Malignancies: Dermatofibrosarcoma Protuberans (DFSPa rare skin tumor) and Aggressive Systemic Mastocytosis (ASM).
Essential Safe Administration
- Take with Food: To prevent severe gastric irritation and nausea, take the tablet with a full meal and a large glass of water.
- Do Not Alter: Swallow the tablet whole. If you have severe trouble swallowing, it can be disintegrated completely in a 200 ml glass of water or apple juice and drank immediately.
- Avoid Grapefruit: Grapefruit and its juice significantly increase blood levels of this medication, sharply raising your risk of drug toxicity.