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440 mg Canmab

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Product Details:

Salt Composition Trastuzumab (440 mg) + excipients
Dosage Form Lyophilized Powder for Injection
Indication HER2-positive breast cancer, HER2-positive metastatic gastric cancer
Feature Monoclonal antibody; high purity and efficacy; biosimilar to Herceptin
Ingredients Trastuzumab, excipients (histidine, trehalose, polysorbate 20)
Application Intravenous infusion after reconstitution
Ph Level Approximately 6.0
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440 mg Canmab Price And Quantity

Minimum Order Quantity 100 Kit

440 mg Canmab Product Specifications

Application Intravenous infusion after reconstitution
Storage Instructions Store at 2C to 8C. Do not freeze.
Shelf Life 36 months
Feature Monoclonal antibody; high purity and efficacy; biosimilar to Herceptin
Fermentation Smell Odorless
Indication HER2-positive breast cancer, HER2-positive metastatic gastric cancer
Physical Color/Texture White to pale yellow lyophilized powder
Ingredients Trastuzumab, excipients (histidine, trehalose, polysorbate 20)
Salt Composition Trastuzumab (440 mg) + excipients
Ph Level Approximately 6.0
Dosage Form Lyophilized Powder for Injection

Pack Size 440 mg single-use vial
Packaging Type Glass vial with flip-off cap
Compatibility Dilute with 250 mL sodium chloride (0.9%)
Therapeutic Class Antineoplastic (Monoclonal Antibody)
Prescription Status Prescription only
Route of Administration Intravenous
Market Authorization DCGI approved
International Nonproprietary Name (INN) Trastuzumab
Reconstitution Solvent Bacteriostatic water for injection (not supplied with vial)

Product Description

Canmab 440mg Injection is used in the treatment of breast and stomach cancer. It works by killing the cancer cells by inhibiting HER2 (human epidermal growth factor receptor protein).

Canmab 440mg Injection is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, headache, rash, insomnia, and infection. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. You must have to inform your doctor if you experience breathlessness, cough, shivering, swelling of legs and arm.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Targeted Therapy for HER2-Positive Cancers

Canmab delivers effective targeted treatment for patients diagnosed with HER2-positive breast and metastatic gastric cancers. This monoclonal antibody specifically attaches to HER2 receptors, interrupting cancer cell growth and leading to improved patient outcomes. Its biosimilar formulation ensures accessibility and therapeutic equivalence to Herceptin.

Safe and Simple Preparation Process

Before intravenous administration, Canmab must be reconstituted with bacteriostatic water for injection and subsequently diluted with 250 mL 0.9% sodium chloride solution. The final solution is infused through a drip, ensuring controlled and accurate delivery. The product is provided in a white to pale yellow, odorless powder, facilitating straightforward handling during preparation.

Reliable Quality and Regulatory Assurance

Manufactured to high standards, Canmab is DCGI approved and meets stringent quality requirements as a monoclonal antibody therapy. Its packaging, handling, and shelf-stability make it a dependable option for healthcare providers, distributing within India under strict prescription-only regulations.

FAQ's of 440 mg Canmab:

Q: How is Canmab 440 mg prepared and administered?

A: Canmab 440 mg must first be reconstituted with bacteriostatic water for injection (not supplied with the vial) to dissolve the lyophilized powder. After reconstitution, the solution is diluted in 250 mL of 0.9% sodium chloride and administered as an intravenous infusion.

Q: What are the main clinical indications for Canmab?

A: Canmab is prescribed primarily for the treatment of HER2-positive breast cancer and HER2-positive metastatic gastric cancer. It acts by targeting the HER2 receptors on cancer cells, thereby inhibiting tumor growth.

Q: When should Canmab therapy be initiated?

A: Canmab therapy should be started once HER2-positivity is confirmed and a prescription has been provided by a qualified healthcare professional, in accordance with clinical guidelines and patient-specific requirements.

Q: Where should Canmab be stored before use?

A: Canmab should be stored in a refrigerator at temperatures between 2C and 8C. It must not be frozen, and should remain in its original packaging until ready for use to ensure stability and potency.

Q: What benefits does Canmab offer compared to other therapies?

A: As a biosimilar to Herceptin, Canmab offers equivalent efficacy and safety at a potentially lower cost. Its high purity monoclonal antibody formulation ensures reliable cancer targeting and a favorable therapeutic profile.

Q: What is the process for reconstituting and diluting Canmab for infusion?

A: First, add the recommended volume of bacteriostatic water for injection directly into the vial to dissolve the powder. Gently swirl (do not shake) until fully dissolved, then withdraw the solution and add it to 250 mL of 0.9% sodium chloride solution, mixing gently for intravenous infusion.

Q: Who can prescribe and supply Canmab 440 mg?

A: Canmab is available by prescription only and must be prescribed by a qualified oncologist or healthcare provider. Distribution is handled by authorized pharmacies, distributors, and suppliers in India, under the approval of the DCGI.

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